Single-stranded DNA-binding proteins (SSBs) are central guardians of genome integrity, selectively coating exposed single-stranded DNA (ssDNA) intermediates that arise during replication, ...

Scientists have uncovered new DNA-binding proteins from some of the most extreme environments on Earth and shown that they can improve rapid medical tests for infectious diseases. The work has been ...

A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by ...

New single-cell method maps protein-DNA interactions, revealing gene regulation changes and advancing multi-omics studies of health and disease. (Nanowerk News) A new technology allows scientists to ...

Figure 1. Design and synthesis of circAMO . (a) Synthesis of a single-molecule ring by rigid regulation of selectivity; (b) Schematic diagram of circAMO design; (c) Synthesis of circAMO; (d) ...

A new molecular recording strategy is giving researchers a way to capture DNA–protein interactions in single cells, including the weak and transient contacts that shape gene regulation but often slip ...

The left-handed spiral of each Z-DNA strand is highlighted on the left. Binding and bonding of the two zinc finger domains (shown in red) from the CTCF protein to Z-DNA (shown in blue). This protein ...