RhoA, a small GTPase, plays a pivotal role in various diseases, including spinal cord injury (SCI). Although RhoA inhibition has been traditionally viewed as beneficial for SCI repair, recent clinical ...

An essential and defining characteristic of microglia is their ability to rapidly remodel their attributes and shift into a wide array of distinct functional states 1,2,3. Historically, microglial ...

Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated ...

In the microglia fully tiled brain, the proliferation and migration of microglia are inhibited by their neighboring cells. When the neighboring microglia are removed, the lateral inhibition is ...