In the life sciences, cryogenic electron microscopy (cryo-EM) has revolutionized structure determination by providing atomic-resolution structures of biomolecules in their native environment and in ...

Our understanding of eukaryotic cell function at the fundamental level of molecular structures and interactions remains incomplete. Although individual components can be studied in isolation or in ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

From paints and inks to catalysts and drug-delivery materials, many advanced technologies rely on substances dispersed in organic solvents. Yet directly observing these materials in their native ...

In a basement lab in Brandeis' Rosenstiel building, a refrigerator-sized microscope dominates a small, windowless room. On its surface, it looks like a featureless white box. Yet inside, it's a study ...

Cryo-correlative light and electron microscopy (cryo-CLEM) is a powerful technique that combines fluorescence imaging for specific localization with electron microscopy for detailed structural ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Electron microscopy is a powerful technique that provides high-resolution images by focusing a beam of electrons to reveal fine structural details in biological and material specimens. 2 Because ...

The Cryo-Electron Microscopy Center supports industry, academic, government, and non-profit research institutes, providing single-particle and microcrystal electron diffraction capabilities. We offer ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open ...